PYROGENAL - Highly active broad-spectrum non-specific immunomodulator (12 suppositories)

PYROGENAL is a broad-spectrum immunomodulator, primarily working by activating the reticuloendothelial, hypothalamic-pituitary, and fibrinolytic systems.

Pyrogenal exhibits adjuvant, desensitizing, and anti-inflammatory effects, enhances overall and specific immune resistance, and influences the thermoregulatory centers in the hypothalamus.
By stimulating phagocytic cells, it promotes phagocytosis, the release of reactive oxygen species, and the production of interleukins (IL-1, IL-2), tumor necrosis factor (TNF-α), and interferons (IFN-α).
Through its action on fibroblasts, it reduces collagen synthesis and accelerates fibrocyte maturation. It enhances hyaluronidase activity, improving tissue permeability, supporting fibrinolysis, restoring blood flow, preventing scar and adhesion formation, resolving existing adhesions, preventing vascular obstruction, and promoting tissue regeneration and epithelial repair.

Stimulates adrenal cortex activity: exhibits anti-inflammatory effects, elevates hormone levels in the bloodstream, and activates the kinin system.

Indications:

Pyrogenal affects multiple organs and systems, which makes it suitable as a non-specific therapeutic agent for a variety of conditions.

This preparation is used for non-specific treatment of chronic liver disorders, urethral and ureteral strictures, chronic prostatitis and urethritis, inflammatory diseases of the uterine appendages, abdominal adhesions, burns, and sexually transmitted infections. It is also applied for immunoprophylaxis and immunorehabilitation in cases of incomplete recovery following acute bacterial or viral infections.

The ease of use of suppositories, proven clinical effectiveness in various conditions, and good patient tolerability allow for outpatient administration.

Use during pregnancy and breastfeeding:

Use during pregnancy and lactation is not recommended, as clinical studies have not been performed.

Contraindications:

Pyrogenal should not be used in patients with acute febrile illnesses or known hypersensitivity to the preparation.
Patients with controlled cardiovascular diseases or diabetes may use the suppositories.

Precautions:

Use this preparation only under a doctor's guidance. Dosage and treatment schedule should be individualized based on the condition, patient age, and preparation tolerance.

Side effects:

Administration of suppositories is generally well tolerated. Mild fever (37.0–37.5°C) and slight malaise may occur in some patients.
Report any unexpected reactions to your healthcare provider.

Drug interactions:

Pyrogenal is compatible with preparations for the aforementioned conditions and may enhance the effectiveness of specific chemotherapeutic treatments when used in combination.

Dosage and administration:

Suppositories are administered rectally, one per day at night. Administration can be daily or every other day, as prescribed.
The starting single dose is 50 mcg, with a maximum single dose of 200 mcg. A typical course consists of 12–15 suppositories.

Recommended dosing schedule: 50, 50, 50, 100, 100, 100, 150, 150, 150, 200, 200, 200 mcg, or as individually directed by a physician.
For monotherapy aimed at immunoprophylaxis or immunorehabilitation after bacterial or viral infections, 50–100 mcg per day is recommended, for a course of 5–10 suppositories.

Under medical guidance, intramuscular injection combined with suppositories may also be used.

Overdose:

No cases of overdose have been reported.

Special instructions:

Women of reproductive potential should use contraception while taking this preparation.

Excipients:

Contains lanolin, which may cause local skin reactions, such as contact dermatitis.

Impact on driving and operating machinery:

Does not impair the ability to drive or perform tasks requiring alertness and quick reactions.

Storage:

Store in a dark place at 2–8°C.

Shelf life:

2 years. Do not use after expiration date.

Packaging:

12 suppositories per set – 3 suppositories of each concentration (50, 100, 150, 200 mcg) in a blister pack, with instructions included.

Guaranteed authenticity and quality:

100% Original from MEDGAMAL (Russian Federation)

The MEDGAMAL branch of the Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health is one of the oldest enterprises producing medical immunobiological products in Russia.

The production technologies for the current preparations, and many others that have been transferred to other manufacturers, have been developed and implemented directly by the branch's employees, working with the institute's leading specialists.

The branch's specialists are working to improve existing technologies and produce competitive products. Currently, extensive work is underway to modernize the existing production facility and bring it into compliance with GMP standards.

Development and production:

MEDGAMAL