DRUGS CONTAINING REGULATORY PEPTIDES

The category includes drugs from different manufacturers and for various purposes, containing peptide complexes.

DALARGIN Ellara is used as part of combination therapy for peptic ulcer of the stomach and duodenum in the acute phase; acute pancreatitis; pancreatic necrosis. Lyophilisate for solution preparation. 10 ampoules of 1 mg. Active ingredient: Tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate. Synthetic hexapeptide, analogue of leucine-enkephalin. Suppresses proteolysis and promotes healing of gastric and duodenal ulcers. It has moderate antisecretory activity, reduces the acidity of gastric juice.

Suppresses the external secretion of the pancreas in response to various stimuli. In case of damage to the pancreas, the drug reduces hyperfermentemia, limits the foci of necrosis and promotes their replacement with a full-fledged tissue, weakens the synthesis of proteolytic enzymes by the pancreas.

DALARGIN Ellara

Indications for use DALARGIN NMICK (NATIONAL MEDICAL RESEARCH CENTER FOR CARDIOLOGY) 1mg 10 ampoules lyophilisate for solution preparation: gastric ulcer and duodenal ulcer; pancreatitis; pancreatic necrosis; obliterating diseases of the arteries; alcoholism. Active ingredient: Tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate. Synthetic hexapeptide, analogue of leucine-enkephalin.

DALARGIN NMICK

DALARGIN Microgen solution for intravenous and intramuscular administration. 10 ampoules of 1 ml. Synthetic hexapeptide, analogue of leucine-enkephalin. Suppresses proteolysis and promotes healing of gastric and duodenal ulcers. It has moderate anti-secretory activity, reduces the acidity of gastric juice. Active substance: Dalargin (Tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine-diacetate [in terms of tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine]) - 1 mg

DALARGIN Microgen

GLUTOXIM Glutoxim is considered as part of a new class of regulators of the body's internal defense systems (innate defense regulators, IDRs) with inherent drug effects: toxic-modifying, immunomodulatory, cytoprotective. Glutoxim® characterizes the ability to initiate redox processes of the formation of disulfide bonds in the structure of extracellular and surface-cellular molecules of a peptide nature.

Glutoxim is an innovative drug, the only registered representative of a new class of regulators of the body's internal defense systems. It has an immunomodulatory effect and is the only drug approved for clinical use from the group of regulators of the body's own defense systems; Leads to the formation of a functionally active structure of internal hematopoietic stimulators and receptors for them, which normalizes hematopoiesis and blood composition; Increases the number of receptors in a functionally active state. During drug therapy, the effect on the xenobiotic receptor is imitated - the cell produces protective enzymes and is more resistant to adverse effects; It suppresses the ability of tumor cells to remove medicinal substances aimed at their destruction, as well as molecules synthesized by cells of the immune system.

GLUTOXIM

MOLIXAN (inosine glycyl-cysteinyl-glutamate-disodium) helps prevent infection with respiratory viral infections, including coronavirus infection COVID-19. In case the disease has already developed, Molixan® reduces symptoms, promotes more effective treatment and speeds up recovery. Improves microcirculation and rheological properties of blood; Optimizes oxygen saturation of tissues, contributing to a more complete utilization of arterial blood oxygen; Improves the energy supply of cells, in particular, the heart, brain and liver; Increases the stability of cell membranes in areas with poor blood supply, increases the resistance of cells to oxygen deficiency; It has anti-inflammatory activity, prevents the development of fibrosis; Increases the activity of detoxification enzymes in the liver, reduces the toxicity of various compounds, inhibits the replication of DNA and RNA viruses; Increases functional and metabolic activity, absorption and digestion capacity of macrophages, production of interferons.

MOLIXAN

ALLOKIN-ALFA (Alloferon) is an oligopeptide. The nature of the pharmacological action is most similar to interferon alpha. Alloferon is an effective inducer of the synthesis of endogenous interferons and an activator of the natural killer system, capable of stimulating the recognition and lysis of defective cells by cytotoxic lymphocytes. The experiments demonstrated high efficiency against infections caused by influenza A and B viruses, hepatitis B and C, herpes types 1 and 2 and human papilloma. Alloferon does not have general toxicity, allergenic properties, mutagenic and carcinogenic effects, does not have an embryotoxic effect and does not affect reproductive function.

The drug is an antiviral, immunomodulatory agent.

Active ingredient: Alloferon (histidyl-glycyl-valyl-seryl-glycyl-histidyl-glycyl-glutaminyl-histidyl-glycyl-valyl-histidyl-glycine). Allokin-alfa 1 mg 6 pcs. bottle of lyophilisate for solution preparation for intramuscular injection.

ALLOKIN-ALFA

RENOBRAIN CM is used in the complex therapy of cerebrovascular accidents, traumatic brain injury and its consequences, encephalopathies of various origins, cognitive impairments (memory and thinking disorders), acute and chronic encephalitis and encephalomyelitis, epilepsy, asthenic conditions (suprasegmental vegetative disorders), reduced ability to learning, delayed psychomotor and speech development in children, various forms of cerebral palsy. Renobrain SM 10 mg 10 pcs. bottle of lyophilisate for solution preparation for intramuscular injection.

The drug contains a complex of low molecular weight water-soluble polypeptide fractions that penetrate the blood-brain barrier directly to nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.
Nootropic - improves higher brain functions, learning and memory processes, concentration, stability under various stressful conditions.
Neuroprotective - protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.
Antioxidant - inhibits lipid peroxidation in neurons, increases the survival of neurons under conditions of oxidative stress and hypoxia.
Tissue-specific - activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, improves the functions of the cerebral cortex and the general tone of the nervous system.

RENOBRAIN SM

PANAVIR - purified extract of the shoots of the plant Solanum tuberosum; the main active ingredient is a hexose glycoside, consisting of glucose, rhamnose, arabinose, mannose, xylose, galactose, uronic acids. Panavir® is an antiviral and immunomodulatory agent. It increases the body's nonspecific resistance to various infections and promotes the induction of alpha and gamma interferons by blood leukocytes. In therapeutic doses, the drug is well tolerated.

Tests have shown the absence of mutagenic, teratogenic, carcinogenic, allergenic and embryotoxic effects. In preclinical studies on laboratory animals, no negative effects on reproductive function and fetal development have been established. It has anti-inflammatory properties in experimental models of exudative edema, chronic proliferative inflammation and in the test of pseudo-allergic inflammatory response to concanavalin A. An analgesic effect was shown on models of neurogenic pain and pain caused by the inflammatory process and thermal irritation. Has an antipyretic effect. Neuroprotective properties are shown on the model of parkinsonian syndrome caused by the systemic administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. It has the ability to improve the function of the retina and optic nerve. It has wound-healing properties in conditions of a model of gastric ulcer.

Active ingredient: Solanum tuberosum shoot polysaccharides.

PANAVIR

FERTIWELL is a complex of polypeptides isolated from the testes of mature cattle. Being a peptide regulator, Fertiwell has an organotropic effect on the male gonads, restoring spermatogenesis and improving spermogram parameters.

According to the results of clinical studies of Fertiwell, it was found that in 84% of men with oligoastenozoospermia, the drug statistically significantly increases the number of spermatozoa and the proportion of their progressively mobile forms. In 36% of men with teratozoospermia, Fertiwell increases the absolute number of morphologically normal forms of spermatozoa in the ejaculate (million/ml). The effect of Fertiwell on pregnancy rates has not been studied in clinical trials.

The drug Fertiwell is an extract containing a complex of peptides and biologically active substances, which does not allow for the usual pharmacokinetic analysis of individual components. In tissues, peptides are cleaved by cellular proteases to amino acids; as a result, the therapeutic effect does not correlate with the determined amounts of peptides and metabolites. Indications: complex therapy of disorders of spermatogenesis (oligoastenozoospermia), accompanied by impaired fertility in men.

FERTIWELL