NEUROPROTECTORS & NEUROPROTECTIVE PEPTIDE REGULATION

Neuroprotection refers to strategies and agents that protect the central nervous system (CNS) from injury caused by ischemia, trauma, neurodegenerative diseases, or excitotoxicity. Neuroprotectors include a wide range of molecules - both synthetic and endogenous - that reduce neuronal death and preserve neurological function.

Among neuroprotectors, neuroprotective peptides have gained attention due to their potent, targeted, and often multifunctional effects. These peptides can modulate inflammation, inhibit apoptosis, and promote neuronal survival and repair. Examples include cerebrolysin which show efficacy in models of Alzheimer's disease, stroke, and traumatic brain injury.

The regulation of neuroprotective peptides involves complex signaling pathways. Many of these peptides act through receptors , influencing downstream cascades like. Importantly, neuropeptides not only support neuronal growth but also upregulate the expression of other protective factors, creating a positive feedback loop in the neuroprotective network.

Recent advances in peptide engineering and delivery systems, including nanoparticles and intranasal administration, have enhanced the stability and brain penetration of these agents. As a result, neuroprotective peptides represent a promising therapeutic avenue for CNS disorders. Ongoing clinical trials are exploring their efficacy and safety profiles, paving the way for future treatment paradigms.