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NOOTROPICS - neurometabolic stimulants

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NOOTROPICS are neurometabolic stimulants that have a positive effect on complex psychophysiological processes. The mechanism of their action is associated with the restoration of the bioenergetic and metabolic functions of the neuron, as well as the neurotransmitter systems of the brain. The principle of operation of nootropic drugs, as their name suggests, is aimed at improving the functioning of the parts of the brain that are responsible for learning, memory, attention and other cognitive functions. 

Nootropics are drugs containing organic or synthetic active substances, as well as their derivatives, which stimulate the functioning of neurotransmitters.

The term nootropics was introduced in 1972 to describe the effects of piracetam on the sensory-cognitive sphere. Later, similar effects were noticed in other substances or complexes of substances. Nootropics used today in medicine are presented in the international drug classification system ATC (Anatomical Therapeutic Chemical), adopted by the Ministry of Health of the Russian Federation in 2002. In some countries, nootropic drugs are not recognized or used.

APPLICATION OF NOOTROPICS

Psychiatrists and psychotherapists prescribe nootropics as monotherapy or in combination with other psychotropic drugs in the treatment of neuroses, attention deficit hyperactivity disorder, depressive disorders. Nootropics are used to restore the cognitive functions of the brain, which are responsible for the processes of interaction with received information: perception, processing, analysis, memorization, storage, conclusions.
Nootropics are used in pediatrics to restore amino acid deficiency, which disrupts protein biosynthesis in the body and metabolic processes. Nootropics are prescribed for children with signs of delayed speech and mental development, mental retardation, and the consequences of perinatal damage to the central nervous system. Speech therapists, neurologists, endocrinologists, gynecologists, urologists, ophthalmologists prescribe nootropics for various diseases and conditions: neuroleptic syndrome, stuttering, logoneurosis, hyperkinesis, dyskinesia, urination disorders, insomnia and other sleep disorders, headaches of various etiologies, dizziness, motion sickness, open-angle glaucoma, retinal vascular diseases, macular diseases, diabetic retinopathy, Alzheimer's disease, Parkinson's disease, Huntington's disease, and the consequences of TBI.
The range of use of nootropic drugs is wide and is not limited only to mental disorders. The gentle therapeutic mechanism of drugs in this group allows nootropics to be prescribed to newborns and infants, as well as the elderly. Nootropics are included in the list of vital and essential drugs for medical use. 

MECHANISM OF ACTION OF NOOTROPIC DRUGS

The mechanism of action of nootropics has not been fully studied to date. However, the principle underlying the therapeutic effect, repeatedly confirmed in vivo, is still of interest to researchers in the fields of biochemistry, cytology and pharmacology. In particular, researchers know that the effectiveness of nootropics in clinical medicine is associated with several mechanisms observed at the cellular level in the CNS: they increase the synthesis of ATP and its derivatives; enhance the process of synaptic transmission in the central nervous system; enhance the plastic process in the central nervous system by increasing the synthesis of RNA and proteins; enhance the process of glucose utilization; have a membrane-stabilizing and antioxidant effect.
Thus, the mechanism of action of nootropic drugs is associated with the restoration of metabolic and bioenergetic processes in the brain, which affect a person’s mood, performance and well-being. A correctly selected nootropic will have the effects necessary for treatment, which manifest themselves over a long period of time, provided that the recommendations of the attending physician are followed (for example, regarding a rational and healthy lifestyle, attending psychotherapy sessions, taking first-line medications).

EFFECTIVENESS OF NOOTROPICS

The effectiveness of nootropics, in particular, is explained by the therapeutic effect on the neurotransmitter systems of the brain - monoaminergic, cholinergic and glutamatergic. Nootropics help restore the regulation of the synthesis of phospholipids and proteins in neurons, normalize the structure of cell membranes; reduce the oxygen demand of neurons; suppress the formation of free radicals and lipid peroxidation of cell membranes; increase the protection of neurons to adverse factors affecting their proper functioning.

The results of biochemical blood tests and EEG, as well as laboratory experiments using modern microscopes, allow us to visualize the effectiveness of nootropics. For example, the results of an electroencephalogram can clearly see the effect of using nootropics - increased amplitudes of transcallosal evoked potentials, enhanced power spectrum of the EEG of the cortex and hippocampus, an enlarged dominant peak, smoothed interhemispheric asymmetry.

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NOOTROPICS - neurometabolic stimulants

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