ZINC THYMULIN (10mg) thymus peptide an effective immunostimulant
10 mg, lyophilizate
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ZINC THYMULIN is a unique thymus peptide, and by all criteria corresponds to the concept of "hormone". Its role in thymus endocrinology has been studied in detail. The secretion of Thymulin by a subpopulation of thymic epithelial cells is controlled by a complex mechanism involving other hormones (prolactin, growth hormone, adrenocorticotropic hormone, thyroxine, beta-endorphin, etc.) and decreases in the blood in many diseases, as well as with age. antiviral activity, the ability to activate local immunity and anti-inflammatory properties.
Since zinc is included in the composition of functionally active thymulin, the level of Thymulin depends primarily on this metal. A significant decrease in thymulin levels is often the result of a lack of zinc, and the introduction of an increased amount of zinc into the diet restores Thymulin levels, although the amount of zinc in the blood plasma remains at the same level.
It was found that in many diseases accompanied by immunodeficiency conditions (Crohn's disease, acute lymphoblastic leukemia, glaucoma), there is a decrease in Thymulin activity and the amount of zinc in the blood.
The level of Thymulin in human serum also depends on various trace elements (selenium, vitamin E), thyroid hormones, toxic elements (mercury, lead) and others, and is determined in blood plasma by various methods, including radioimmunoassay and electrophoresis.
Changes in the level of Thymulin in the blood of healthy people from the first days of life to old age (80 years) have been studied in detail. Thymulin is detected immediately after the birth of a child, then gradually its level rises, reaching a maximum at the age of 5-10 years. Starting from the puberty, the level of Thymulin in the blood serum gradually decreases, reaching the lowest values at the age of 35-36 years and remains at this level unchanged until the end of a person's life.
Thymulin, in addition to the effect known for all thymic preparations on the processes of maturation and functioning of T cells, also has an effect on the macrophage-phagocytic system, the functions of natural killer cells and other parameters of the immune system. Its effect on the endocrine and nervous system occurs through the regulation of the secretion of adrenocorticoid hormone, luteinizing hormone and prolactin, as well as other hormones. In turn, the synthesis of Thymulin depends on the neuroendocrine system, and he himself plays an important role in the pituitary-thymic connections.
Recently, there has been great interest in the possibility of using this immunomodulatory drug in the clinic. In experiments showing the effectiveness of Thymulin in the treatment of rheumatoid arthritis and hyperalgesia. The neuroprotective effect of Thymulin on the central nervous system, its ability to reduce pain (analgesic properties) with local and intraperitoneal administration has been proven. Thymulin acts directly on afferent nerve endings and affects the synthesis of prostaglandin E. It is assumed that in the future it will be possible to use this thymic hormone as an analgesic and anti-inflammatory drug.
Developments are reported to create a synthetic Thymulin gene. It has been shown that Thymulin helps to reduce the toxic effect of certain chemicals on the human body, for example, lead, which is very important for the creation of antitoxic drugs. It has been proven that Thymulin exhibits an antitumor effect, reduces intoxication caused by chemotherapy in the complex treatment of tumors, prevents the nephrotoxic effect of certain drugs, reduces the degree of development of acute graft versus host disease, etc.
Quantity: 10 mg
Purity: over 97%
Form: lyophilizate
Excipient: zinc, mannitol
Storage: no more than +5C
Amino acid sequence: Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH
Molecular weight: 858.85
Molecular formula: C33H54N12O15
Synonyms: ZT, Zinc-Timulin, Thymalin, Thymalin, Thymulin, Thymalin, thymic factor, facteur thymique serique, FTS, Zn-FTS
Main area of research: immunity, thymus, differentiated T-cells, alopecia.
Structural formula Thymulin:
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100% original product from RUSSIAN PEPTIDE (Russian Federation)
RUSSIAN PEPTIDE is a commercial, innovative technology-based organization providing a full range of services to the pharmaceutical, biotechnology and cosmetics industries.
The company specializes in the development of technology and production of peptides and complex organic molecules as biologically active ingredients and their intermediates, biochemical substances for in vitro research purposes, reference standards for the calibration of analytical equipment, as well as reagents for peptide synthesis.
Development and production:
RUSSIAN PEPTIDE is a commercial, innovative technology-based organization providing a full range of services to the pharmaceutical, biotechnology and cosmetics industries.
