FOLLICLETIDE SPRAY(30ml) - peptide composition for hair health and growth

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FOLLICLETIDE  is a peptide composition for hair health and growth, to activate follicles, stimulate hair growth.

Peptides have long been used to stimulate hair growth. Unlike conventional baldness treatments, which are accompanied by adverse reactions, hair growth peptides are non-toxic, do not cause side effects or addiction. A combination of peptides acting on different mechanisms of hair growth, stimulating follicle development, strengthening them and improving blood circulation, can provide a maximum, synergistic effect and significantly improve hair growth and health. The most well studied peptides for hair growth include tripeptides GHK-Cu, AHK-Cu, Biotin-GHK, Pal-GHK and Pal-AHK, tetrapeptides Ac-SDKP, Ac-KGHK and PTP20, biologically active fragments of Thymosin β4, Zinc- Thymulin and PTD-DBM polypeptide.

GHK-Cu copper tripeptide complex is a carrier signal peptide with the amino acid sequence (Gly-His-Lys-)2·Cu discovered in the 1970s for its role in copper transport and hepatocyte survival. Since then, it has been noted as a growth factor for various cells and a stimulator of tissue regeneration. GHK-Cu and related oligopeptides such as Pal-GHK are almost non-irritating to the skin, making GHK derivatives suitable for topical application. The benefit of GHK-Cu is to stimulate the synthesis of extracellular matrix by selectively increasing the expression of the metalloproteinase-2 enzyme, which plays a role in the formation of new blood vessels (angiogenesis) and the breakdown of large aggregates of collagen IV into scars, promoting the formation of beneficial collagen I. The enzyme also creates an anti-inflammatory environment . As a modulator of metalloproteinase-2, GHK-Cu is referred to as matrixin. Cosmeceutical, meaning both cosmetic and therapeutic, uses of GHK-Cu include anti-aging, skin hydration, and hair growth stimulation. In clinical trials, the peptide showed a significant improvement over placebo in all respects. A solution of copper-1 tripeptide with a concentration of about 0.05% perfectly restores and remodels the skin, helping to improve the nutrition of hair follicles.

AHK-Cu has the amino acid sequence Ala-His-Lys-Cu and is used in hair and scalp growth and care products. The AHK peptide has an affinity for copper ions, was originally isolated from human plasma and described as a growth factor for various cells and an extracellular matrix modulator. A study of cultured dermal papilla cells confirmed that AHK-Cu affects hair growth, cell division and cell death in the papillary dermis, and promotes the growth of human hair follicles. AHK-Cu is similar to GHK-Cu and has a stronger effect on hair growth. Also, AHK-Cu is generally used more for hair care than GHK-Cu. 

Biotin-GHK has the sequence Biotin-Gly-His-Lys and is used to increase the production of adhesive proteins, keratinocytes, to prevent hair loss, strengthen eyelashes and eyebrows. The addition of a biotin fragment to GHK enhances the affinity of the peptide for hair keratin, which facilitates its penetration and increases biological activity. An ex vivo study showed that biotinyl-GHK modulates the migration of keratinocytes - skin epidermal cells, remodeling and the formation of collagen and laminin. Biotinyl-GHK enhanced hair growth in vitro, increasing hair length by 58–120%. Evidence for better attachment of hair to the follicular pocket was provided in a clinical study of hair loss in patients with alopecia where there was a significant improvement in the ratio of anagen to telogen phases, consistent with histological observations of participants' plucked hair.

Ac-SDKP peptide is a thymosin β4 fragment with the sequence Ac-Ser-Asp-Lys-Pro, which is commonly found in serum and other body fluids. This sequence is not found in other proteins, and a decrease in the concentration of Tβ4 reduces the level of Ac-SKDP in the blood serum. Ac-SDKP has various biological activities important for repair mechanisms. Initially, this peptide was found to inhibit the proliferation of pluripotent hematopoietic stem cells, and then, which promotes angiogenesis in vitro and in vivo in various models, reduces inflammation and prevents fibrosis. Angiogenesis is important for the blood supply to hair follicles. The acetyl derivative of SDKP penetrates the skin better and is considered a cosmetic product, since the molecular mechanisms of aging therapy and wound healing are somewhat similar. Clearly, Ac-SDKP can promote healthy hair and scalp growth.

KGHK peptide with the sequence Lys-Gly-His-Lys-NH2, which is able to bind copper ions, is able to stimulate the formation of endothelial cell networks and increase the production of progesterone. The peptide has a direct effect on the hair follicle. The remodeling signal peptide stimulates the growth of new vessels, increases the size of the hair follicle for better fixation and vitality of the hair. The acetylated form, Ac-KGHK, has increased bioavailability and can improve hair growth and health, anchor hair shafts in the dermis, prevent graying, and help with androgenetic alopecia. The peptide has a rejuvenating effect and is part of hair growth products. 

Zinc thymulin is used for androgenetic alopecia. Zinc and thymulin are two natural compounds involved in the growth of hair follicles. Their combination in the form of a complex is more effective, since zinc, as an important microelement, has a powerful and specific effect on the thymus gland. The lack of zinc in the body causes hair loss, which is shown in the study of individuals with alopecia. Timulin has a neuroendocrine effect. Thymus gland extract stimulates hair growth, in turn, zinc improves the condition of the hairline, regulating the division of hair follicle cells and stimulating the synthesis of collagen and keratin.

Actin-TB4(17-23) is a protein involved in the polymerization of G-actin, which, in turn, forms F-actin protein filaments, microfilaments, which are the basis of the cytoskeleton and provide mechanical strength to cells. Thymosin β4 plays a key role in the growth and development of the hair follicle: it stimulates the differentiation and migration of stem cells, promotes the growth of blood vessels, improves nutrition of the follicles, and suppresses inflammation.

PTD-DBM polypeptide effectively stimulates the restoration of the hairline, especially in combination with valproic acid, and has a wound healing effect.
PTD-DBM works on a protein responsible for hair loss in androgenetic alopecia. The peptide promotes the formation of new hair follicles.

Quantity: 30 ml

Purity: over 97%

Form: solution in a spray dispenser

Excipient: purified water, glycerin, methylparaben

Storage: no more than +5C

Peptide composition: GHK-Cu, Biotin-GHK, AHK-Cu, Ac-SDKP, Ac-KGHK, Ac-TB4(17-23), Zink-Thymulin, PTD-DBM, PTP20

Synonyms: Фолликулитид, Фолликултаид, Фолликултид, Фолликлетид

Main area of research: hair health and growth, follicle activation, hair growth stimulation

Indications for use: androgenetic alopecia, related to non-scarring form, aging, weakening of hair, gray hair, unfavorable environmental conditions

By purchasing Russian Peptide product samples from this site, you understand that they are for research purposes only and not for the treatment of humans or animals.

Method of application:

The products are for professional use only. Peptide products are intended for research and scientific purposes only.

Guaranteed authenticity and quality:

100% original product from RUSSIAN PEPTIDE (Russian Federation)

RUSSIAN PEPTIDE is a commercial, innovative technology-based organization providing a full range of services to the pharmaceutical, biotechnology and cosmetics industries.
The company specializes in the development of technology and production of peptides and complex organic molecules as biologically active ingredients and their intermediates, biochemical substances for in vitro research purposes, reference standards for the calibration of analytical equipment, as well as reagents for peptide synthesis.

Development and production:

RUSSIAN PEPTIDE is a commercial, innovative technology-based organization providing a full range of services to the pharmaceutical, biotechnology and cosmetics industries.